OVERVIEW OF OUR RESEARCH
The Smaldino laboratory is broadly interested in G-quadruplex nucleic acid structures and the cellular enzymes that unwind them. G-quadruplexes are stable, ‘knot-like’ structures that form within guanine (G)-rich regions of DNA or RNA. These structures provide an essential layer of transcriptional and translational regulation in a healthy cell. However, when in excess or aberrantly unwound, G-quadruplexes can become pathological. We focus our efforts on studying the major human G-quadruplex helicase G4R1 (aliases: DHX36 and RHAU. We apply our expertise in G-quadruplex and G4R1 biology to study normal neuronal development and G-quadruplex-linked diseases including, ALS (Lou Gehrig’s disease), dementia, and cancer. We leverage a combinatorial approach of biochemical assays, human cell culture models, and mouse models to study these topics.
Thank you for your interest in our research. Reach out to us for any questions or comments regarding our work and publications. We would love to hear from you.
2111 W Riverside Ave, Muncie, IN 47306, USA